Information on COVID-19 for patients taking Tremfya®▼ (guselkumab) Read More
how to use tremfya how to use tremfya

how to use tremfya®

what is tremfya

What is Tremfya®?2

Tremfya® comes as an injectable pre-filled pen for administration by subcutaneous injection (under the skin).2

Each injectable of Tremfya® contains 100 mg of guselkumab in a 1mL solution.

How to administer Tremfya®

Please see the video for how to administer Tremfya®.

how often to take Tremfya

How often to take Tremfya®2

Tremfya® is supplied as an injectable pre-filled pen for administration by a subcutaneous injection, meaning an injection under the skin.2

The recommended dose of Tremfya® is 100mg. Your injectable comes with one 100mg dose.

At the beginning of your treatment, you will receive one dose at week 0 and 4 (this is the induction phase) followed by one dose every 8 weeks (maintenance).

The recommended dose of Tremfya® is 100mg. Your injectable comes with one 100mg dose.

At the beginning of your treatment, you will receive one dose at week 0 and 4 (this is the induction phase) followed by one dose every 8 weeks (maintenance).

The dosing schedule for a patient receiving their first Tremfya® dose on 1st January.




























Do you have questions about your Tremfya® dose?

Speak to your doctor or nurse if:

  • You are unsure when your next dose of Tremfya® is due
  • You use more Tremfya® than you should have, such as receiving a larger dose or using it sooner than planned
  • You forget to administer a dose
  • You would like to stop using Tremfya®. Your symptoms may return if you stop treatment

The Tremfya® treatment journey: Year one

If you’re starting Tremfya® and wondering what will happen with your treatment in the first year,
or you would like to understand the results patients participating in clinical studies experienced with Tremfya®, the timeline below has the information

week 0: the starter dose

You will receive your first injection by a doctor or nurse at your hospital or clinic, or by a nurse who visits you at home. The nurse visiting your home may also train you to self-inject, if it is decided that this is an appropriate option for you.

week 4: the second starter dose

Tremfya® is binding to your immune cells!4

week 4: the second starter dose

week 12: the first maintenance dose

This is your first maintenance dose and from now on, all doses will be every eight weeks.2

first maintenance dose

Noticing any changes?

It may be helpful to use a journal or take pictures to document changes in your condition. If you experience any negative symptoms on Tremfya®, contact your healthcare professional immediately.


week 16: visible results

In a clinical study, 7 out of 10 patients saw a 90% improvement in the size of the area of affected skin and severity of psoriasis after 16 weeks of treatment with Tremfya®.5 84.1% of patients achieved cleared or almost cleared skin.5

If your psoriasis hasn’t responded to Tremfya® by now, your healthcare professional may decide to stop or change your treatment.6

As with any clinical trial, patients are selected based upon strict criteria, such as not having another progressive or uncontrolled medical condition, to avoid the data being influenced by their effects.
In real-world practice, patients taking Tremfya® may have other medical conditions or other factors not allowed in the clinical trials. This means clinical trial data does not necessarily reflect real-world treatment, and so your response may differ to patients in these trials.

week 20: the second maintenance dose

Make sure you’re staying in touch with your doctor or nurse in case you have any questions.


week 28: the third maintenance dose

You’re past the halfway mark of your first year on Tremfya®!


week 36: the fourth maintenance dose

Keep tracking your progress to see how far you’ve come.


week 44: the fifth maintenance dose

You’ve almost completed your first year on Tremfya®!


week 52: one year of tremfya®

Your first year on Tremfya® is complete! You will continue to have check-ups with your healthcare professional, to make sure your psoriasis is still responding well to treatment and you’re happy with your medication. If you have concerns or questions at any point, contact your healthcare professional.

after year one

New clinical trial data from 2018 showed that, of 431 patients who stayed on treatment with Tremfya® for three years, 82.8% experienced at least a 90% reduction in the severity of their psoriasis and size of the area affected since they began treatment; 50.8% experienced complete clearance of psoriasis. The study is ongoing, so patients are still being treated in this trial and new data will be available in the future.7

What you need to know before you use Tremfya®2

do not use tremfya

Do not use Tremfya® - +

  • If you are allergic to guselkumab or any of the other ingredients of this medicine. If you think you may be allergic, ask your doctor for advice before using Tremfya®
  • If you have an active infection, including active tuberculosis
warnings and precautions

Warnings and precautions - +

Talk to your doctor, pharmacist or nurse before using Tremfya® if:

  • You are being treated for an infection
  • You have an infection that does not go away or that keeps coming back
  • You have tuberculosis or have been in close contact with someone with tuberculosis
  • You think you have an infection or have symptoms of an infection (see below under ‘look out for infections and allergic reactions’)
  • You have recently had a vaccination or if you are due to have a vaccination during treatment with Tremfya®
look out for infections and allergic reactions

Look out for infections and allergic reactions - +

Tremfya® may lower your ability to fight infections and may therefore increase your risk of infections and allergic reactions. Tell your doctor or seek medical help immediately if you notice any signs of an infection or an allergic reaction while you are taking Tremfya®.

Signs of infection can be:

  • Fever or flu like symptoms
  • Muscle aches
  • Cough
  • Shortness of breath
  • Blood in your phlegm (mucus)
  • Weight loss
  • Shortness
  • Diarrhoea or stomach pain
  • Warm, red, or painful skin or sores on your body which are different from your psoriasis
  • Warm
  • Burning when you urinate, or urinating more often than usual

Signs of allergic reaction can be:

  • Difficulty breathing or swallowing
  • Swelling of the face, lips, tongue or throat
  • Severe itching of the skin, with a red rash or raised bump
children and adolescents

Children and adolescents - +

Tremfya® is not recommended for children and adolescents under 18 years of age because it has not been studied in this age group.

other medicines and tremfya

Other medicines and Tremfya® - +

Tell your doctor or pharmacist:

  • If you are using, have recently used or might use any other medicines
  • If you recently had or are due to have a vaccination. You should not be given certain types of vaccines (live vaccines) while using Tremfya®
pregnancy and breast feeding

Pregnancy and breast-feeding - +

  • Tremfya® should not be used in pregnancy as the effects of this medicine in pregnant women are not known. If you are a woman of childbearing potential, you are advised to avoid becoming pregnant and must use adequate contraception while using Tremfya® and for at least 12 weeks after the last Tremfya® dose. Talk to your doctor if you are pregnant, think you may be pregnant or are planning to have a baby
  • Talk to your doctor if you are breast-feeding or are planning to breast-feed. You and your doctor should decide if you will breast-feed or use Tremfya®
driving and using machines

Driving and using machines - +

Tremfya® is unlikely to influence your ability to drive and use machines.

how to administer tremfya

How to administer Tremfya® - +

Please see the Patient Information Leaflet for instructions on how to administer Tremfya®


MyTremfya Homecare is a free medicine delivery and injection service, available at most hospitals, that gives you the option of taking your medication - Tremfya® - in the comfort of familiar surroundings.
You and your healthcare professional will discuss the type of homecare service that is most appropriate for you.

home delivery

Home delivery

Tremfya® is delivered directly to your home, or to another convenient location of your choice, by a specialist Homecare provider. You’ll just need to make sure there is a fridge for storing the medicine and someone available to sign for the delivery.

home training visits

Home training visits

After receiving your medication delivery, a qualified nurse will visit you in your home or location of your choice to administer your medication and train you to self-administer. You can then move onto receiving regular medication deliveries after successfully completing your training.

home administration visits

Home administration visits

A small number of patients may need continued nurse support, where a nurse will administer the medication. This could be for reasons such as being afraid of needles, or difficulty using your hands.Your healthcare professional will decide if this is appropriate for you.

Possible side effects2

Reporting side effects

This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects you may get. See for how to report side effects.
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at: to Janssen-Cilag Ltd on 01494 567447.

What are the possible side effects?

Like all medications, Tremfya® can cause side effects, although not everyone will get them.

The side effects listed below have all been reported to be mild to moderate in clinical studies. If you experience any of these side effects or they become severe, speak to your healthcare professional as soon as possible:

Very common side effects:2

(may affect more than 1 in 10 people)

  • Upper respiratory infections

Common side effects:2

(may affect up to 1 in 10 people)

  • Headaches
  • Joint pains (arthralgia)
  • Diarrhoea
  • Stomach infections (gastroenteritis)
  • Redness at the injection site
  • Hives
  • Skin fungal infections
  • Herpes simplex infections

Uncommon side effects:2

(may affect up to 1 in 100 people)

  • Pain around the injection site
  • Rash
  • Hypersensitivity